Table 2.
Least-square means of baseline liver fat content by apolipoprotein quintile in MESA.
| Liver Fat Content (95% CI), HU (Lower HU Indicate Higher Liver Fat Content) | ||||||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | P trend | |
| Total apoC3 | ||||||
| Median levels, mg/dL | 5.4 | 7.3 | 8.6 | 10.4 | 13.9 | |
| Model 1 | 61.1 (60.4, 61.8) | 60.5 (59.8, 61.1) | 60.1 (59.4, 60.7) | 58.8 (58.1, 59.4) | 57.1 (56.5, 57.8) | <0.0001 |
| Model 2 | 61.0 (60.2, 61.7) | 60.3 (59.5, 61.1) | 59.9 (59.1, 60.7) | 58.6 (57.8, 59.4) | 57.0 (56.2, 57.8) | <0.0001 |
| Total apoA1 | ||||||
| Median levels, mg/dL | 91.8 | 111.7 | 125.8 | 142.4 | 174.6 | |
| Model 1 | 57.9 (57.2, 58.6) | 59.0 (58.4, 59.7) | 59.8 (59.1, 60.5) | 59.8 (59.1, 60.5) | 61.2 (60.5, 61.9) | <0.0001 |
| Model 2 | 58.0 (57.2, 58.8) | 59.1 (58.3, 59.9) | 59.7 (58.9, 60.4) | 59.7 (58.9, 60.5) | 60.9 (60.0, 61.7) | <0.0001 |
| ApoA1 in HDL that lacked apoC3 | ||||||
| Median levels, mg/dL | 85.9 | 104.7 | 117.7 | 132.8 | 163.2 | |
| Model 1 | 58.0 (57.3, 58.7) | 59.1 (58.4, 59.8) | 59.8 (59.1, 60.5) | 59.9 (59.2, 60.6) | 61.0 (60.2, 61.7) | <0.0001 |
| Model 2 | 58.1 (57.2, 58.9) | 59.2 (58.4, 60.0) | 59.7 (58.9, 60.5) | 59.7 (58.9, 60.5) | 60.6 (59.7, 61.5) | <0.0001 |
| ApoA1 in HDL that contained apoC3 | ||||||
| Median levels, mg/dL | 5.0 | 6.6 | 7.9 | 9.3 | 12.3 | |
| Model 1 | 59.1 (58.4, 59.9) | 59.1 (58.4, 59.8) | 59.4 (58.7, 60.1) | 60.1 (59.4, 60.8) | 60.0 (59.2, 60.8) | 0.71 |
| Model 2 | 59.4 (58.5, 60.2) | 59.2 (58.4, 60.0) | 59.2 (58.4, 60.0) | 59.8 (59.0, 60.6) | 59.8 (58.9, 60.6) | 0.57 |
ApoA1 in HDL that contained or lacked apoC3 was modeled simultaneously; HU, Hounsfield units. Model 1 was adjusted for age, sex, race/ethnicity (White/African-American/Chinese-American/Hispanic) and study site. Model 2 included covariates from Model 1 and was further adjusted for smoking status (current/former/never), alcohol status (current/former/never) and intake (g/day), income (four categories), liver fat-adjusted BMI (kg/m2), and physical activity (MET-hr/week). Test for heterogeneity of regression slopes for apoA1 in HDL that contained or lacked apoC3: Model 1: P = 0.003, Model 2: P = 0.048.