Table 8B.
Comparison of droplet digital PCR (ddPCR) and fluorescence in situ hybridization (FISH) results for detecting CDKN2A homozygous and hemizygous loss.
| cdkn2a ddPCR scoring | FISH CDKN2A homozygous loss | FISH CDKN2A hemizygous loss | FISH CDKN2A no loss | Concordance between ddPCR and FISH | Discordance between ddPCR and FISH |
|---|---|---|---|---|---|
| Homozygous Loss (n=28) | 26 | 2 | 0 | 92% (26/28) | 8% (2/28) |
| Hemizygous Loss (n=10) |
3 | 5 | 2 | 50% (5/10) | 50% (5/10) |
| Homozygous & hemizygous loss (n=38) | 29 | 7 | 2 | 95% (36/38) | 5% (2/38) |
| No Loss (n=1) | 1 | 0 | 0 | Nil | 100% (1/1) |