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Comparison of methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) and CDKN2A droplet digital PCR (ddPCR) homozygous and hemizygous deletion, and no loss (retention).
| CDKN2A ddPCR results | MTAP IHC loss | MTAP IHC retained | Concordance between MTAP IHC and CDKN2AddPCR Homozygous loss |
|---|---|---|---|
| Homozygous Loss (n=28) |
19 | 9 | 68% (19/28) |
| Hemizygous Loss (n=10) | 3 | 7 | 70% (7/10) |
| No Loss (n=1) | 0 | 1 | 100% (1/1) |
| Overall Concordance MTAP IHC and CDKN2A ddPCR as a test | 69% (27/39) |
