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. 2020 Nov 12;8:593685. doi: 10.3389/fcell.2020.593685

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Copyright © 2020 Pin, Huanting, Chengzhan, Xinjuan, Yugong, Wei, Shifang, Zhaojian, Kun, Weicheng, Yingying, Yongming and Yanan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Over-expression of PDCD4 impedes glioma tumorigenesis in vivo. (A) Growth kinetics of glioma cells stably over-expressing PDCD4 following subcutaneous inoculation in nude mice. (B) Kaplan-Meier survival curves of glioma cells stably over-expressing PDCD4 following subcutaneous inoculation in nude mice. (C) Representative immunofluorescence staining images of the indicated glioma tumors. (D) Quantification of Ki67 + proliferating cells in the indicated tumors. (E) Schematic of the proposed model depicting the binding of AKT2 and PDCD4 that regulates the nuclear translocation of p65, and thus leads to cytokine expression and angiogenic activity. **P < 0.01.