Figure 1.

Immunosuppressive network of tumor-derived myeloid cell chemoattractants. (A) Multiple chemokines and cytokines released by pancreatic tumor cells trigger influx of myeloid cells to the tumor microenvironment (TME) that in turn suppress T cells that could otherwise attack the tumor or be induced to do so with immunotherapy. (B) Blockade or neutralization of tumor-derived chemoattractants in numerous mouse models leads to diminution of myeloid cells in the TME, an upsurge in infiltrating T cells, and tumor regression especially after immunotherapy.