Table 2.

Subgroup analysis. Patients were divided into subgroups based on the following criteria: early (Stages 1–2)/ late (Stages 3-4) CKD stage, younger (under 60)/older (over 60) age, and gender so that each patient was ultimately referenced to one of eight possible different subgroups. The final trained model was implemented on each subgroup

	Subgroup size	Positive cases	C- statistics	Sensitivity	Specificity	PPV	NPV
Males ckd S3/S3. Age 60+	1784	164	0.919	0.756	0.931	0.528	0.974
Males,ckd S3/S4, Age 60-	348	44	0.878	0.659	0.908	0.509	0.948
Males ckd S1/S2 Age 60+	1061	16	0.925	0.625	0.983	0.357	0.995
Males ckd S1/S2, Age 60-	559	5	0.968	0.600	0.982	0.231	0.996
Females ckd S3/S4 Age 60+	1862	152	0.918	0.711	0.944	0.529	0.973
Females ckd S3/S4 Age 60-	230	34	0.891	0.765	0.913	0.605	0.957
Females ckd S1/S2 Age 60+	1064	13	0.906	0.765	0.991	0.526	0.997
Females ckd S1/S2 Age 60-	426	10	0.918	0.300	0.993	0.500	0.983