Table 3.
Most affected genes involved in lipid and carbohydrate metabolism after treatment with resveratrol.
| Gene | Description | Human Ortholog | logFC | ANOVA p Value |
|---|---|---|---|---|
| Fatty acid and sterol biosynthesis | ||||
| F49E12.10 | Sterol biosynthesis | FAXDC2 (fatty acid hydroxylase domain containing 2) | −13.27 | 0.0007 |
| F49E12.9/drd-1 | Dietary restriction downregulated-1 | FAXDC2 (fatty acid hydroxylase domain containing 2) | −4.16 | 0.0054 |
| Lipid biosynthesis and fatty acid elongation in mitochondria | ||||
| acdh-1 | Oxidoreductase activity | ACADSB (acyl-CoA dehydrogenase short/branched chain) | −3.90 | 0.0010 |
| W03F9.4 | Carnitine O-palmitoyltransferase activity | −3.64 | 0.0035 | |
| C06E8.5 | Lipid binding activity | BPIFA2 (BPI fold containing family A member 2) | −3.21 | 0.0249 |
| hacd-1 | 3-hydroxyacyl-CoA dehydrogenase activity and NAD+ binding activity | HADH (Hydroxy-Acyl-CoA Dehydrogenase) | −2.90 | 0.0276 |
| cpt-4 | Carnitine palmitoyl transferase | CPT1A, CPT1B, and CPT1C | −2.27 | 0.0098 |
| W02F12.2 | N-acylsphingosine amidohydrolase activity. Sphingosine and ceramide biosinthesis | ACER1 (alkaline ceramidase 1) | −2.22 | 0.0465 |
| fat-7 | Fatty acid and lipid biosynthesis. stearoyl-CoA 9-desaturase activity | SCD (stearoyl-CoA desaturase) and SCD5 | −2.15 | 0.0210 |
| C06G1.1 | Lipid binding activity | BPIFA3 (BPI fold containing family A member 3) | −2.14 | 0.0147 |
| acdh-2 | Oxidoreductase activity | ACADSB (acyl-CoA dehydrogenase short/branched chain) | −2.08 | 0.0304 |
| Fatty acid oxidation and hydrolysis | ||||
| F09C8.1 | phospholipase activity | PLB1 (phospholipase B1) | 3.16 | 0.0050 |
| Y51H4A.5 | hydrolase activity | ND | 3.01 | 0.0064 |
| F25E2.3 | acyl-CoA hydrolase activity | ACOT8 (acyl-CoA thioesterase 8) | 2.16 | 0.0111 |
| Fatty acid and gluthathione metabolism | ||||
| F56A4.3 | glutathione transferase activity | GSTA5 (glutathione S-transferase alpha 5); GSTM1 (glutathione S-transferase mu 1); and GSTM3 (glutathione S-transferase mu 3) | −2.66 | 0.0397 |
| gst-14 | glutathione transferase activity | GSTA4 (glutathione S-transferase alpha 4), GSTA5 (glutathione S-transferase alpha 5), and HPGDS (hematopoietic prostaglandin D synthase) | −2.53 | 0.0154 |
| tyr-2 | Oxidoreductase activity | DCT (dopachrome tautomerase) | −2.44 | 0.0280 |
| mlt-7 | peroxidase activity | EPX (eosinophil peroxidase) | −2.33 | 0.0447 |
| C11E4.1/gpx-5 | glutathione peroxidase activity | GPX5 (glutathione peroxidase 5) and GPX6 (glutathione peroxidase 6) | −2.10 | 0.0186 |