Table 6.
Top upregulated and downregulated genes based on fold change (with ANOVA p < 0.05) following vanillic acid treatment (100 µM).
| Gene | Function | Human Ortholog | logFC | ANOVA p-Value |
|---|---|---|---|---|
| UPRER response genes | ||||
| pqn-57 | Prion-like-(Q/N-rich)-domain-bearing protein. Involved in endoplasmic reticulum unfolded protein response. | ND * | −1.78 | 0.0317 |
| hsp-16.48 | Unfolded protein binding activity. IRE1-mediated unfolded protein response | HSPB1 (heat shock protein family B (small) member 1), HSPB2 (heat shock protein family B (small) member 2) and CRYAA (crystallin alpha A) | 1.51 | 0.0110 |
| hsp-16.2 | Unfolded protein binding activity | HSPB1 (heat shock protein family B (small) member 1), CRYAA (crystallin alpha A), CRYAB (crystallin alpha B) | 1.98 | 0.0111 |
| F44E5.5 | Unfolded protein binding activity, misfolded protein binding activity, ATP binding activity | HSPA14 (heat shock protein family A (Hsp70) member 14); HSPA4 (heat shock protein family A (Hsp70) member 4); and HSPH1 (heat shock protein family H (Hsp110) member 1 | 2.04 | 0.0341 |
| Other stress-response genes | ||||
| C11E4.2/gpx-3 | Glutathione peroxidase activity | GPX3 (glutathione peroxidase 3) | 1.84 | 0.0027 |
| cyp-37B1 | Cytochrome P450 family member with oxidoreductase activity involved in defense response to Gram-positive bacterium. | CYP4A11 (cytochrome P450 family 4 subfamily A member 11); CYP4B1 (cytochrome P450 family 4 subfamily B member 1); and CYP4F3 (cytochrome P450 family 4 subfamily F member 3). | −1.63 | 0.0172 |
| fmo-3 | Monooxygenase activity | FMO5 (flavin containing dimethylaniline monoxygenase 5) | 1.71 | 0.0099 |
| irg-5/CELE_F35E12.5 | Defense response to Gram-positive bacterium. | ND | 1.53 | 0.0393 |
| Other genes | ||||
| gpdh-1 | glycerol-3-phosphate dehydrogenase (quinone) activity and glycerol-3-phosphate dehydrogenase [NAD+] activity | GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like) | 1.7 | 0.0130 |
| arl-6 | Exhibits GTPase activity. Is involved in intracellular transport | ARL6 (ADP ribosylation factor like GTPase 6) | −1.75 | 0.0267 |
| dop-3 | Exhibits dopamine neurotransmitter receptor activity, coupled via Gi/Go | DRD2 (dopamine receptor D2) | −1.53 | 0.0205 |
| aat-7 | l-amino acid transmembrane transporter activity. | SLC7A11 (solute carrier family 7 member 11); SLC7A7 (solute carrier family 7 member 7); and SLC7A9 (solute carrier family 7 member 9) | 1.52 | 0.0027 |
| ugt-63 | UDP-glycosyltransferase activity | ND | 1.52 | 0.0076 |
| glb-33 | Heme binding activity and oxygen binding activity | ND | 1.54 | 0.0222 |
| F35B12.4/piit-1 | Serine-type endopeptidase inhibitor activity | TFPI2 (tissue factor pathway inhibitor 2) | 1.63 | 0.0420 |
| str-130 | G protein-coupled olfactory receptor activity | ND | 1.7 | 0.0226 |
* ND: Not Defined.