FIGURE 1.

Clinical features of the affected members and family information. (A) Pedigree structure of a Chinese family with complex digital anomalies. Squares and circles denote males and females. Filled shapes indicate affected members. Individuals labeled with solidi are deceased. The arrow denotes the proband. Members marked with ^∗ are the participants in this study. (B) Clinical features of the proband (IV-1) showing bilateral type I preaxial polydactyly of big toes with additional digits outside the great toe of the right foot and inside the great toe of the left foot. (C) Clinical features of the individual III-2 showing cutaneous syndactyly among the 3rd and 4th fused digits after the surgery and incomplete osseous syndactyly between the 1st and 2nd fused digits of both hands. Bilateral type I preaxial osseous polydactyly and syndactyly of big toes of both feet, and bilateral cutaneous syndactyly among the 1st, 2nd, and 3rd digits of both feet. (D) Clinical features of individual II-2 showing postaxial polydactyly in the right hand with cutaneous syndactyly between the 3rd and 4th digits of both hands, incomplete osseous syndactyly between the 1st and 2nd fused digits of the hands. Bilateral type I preaxial polydactyly of big toes with additional digits inside the great toes, and cutaneous syndactyly among the 2nd, 3rd, 4th, and 5th fused digits of both feet.