TABLE 1.

Differentially expressed genes of each subtypes.

Cluster	Low expressed NK activator ligands	High expressed NK activator ligands	Low expressed NK inhibitor ligands	High expressed NK inhibitor ligands
Cluster 1	CFP, CLEC2B, CSF1, CSF3, HLA-E, IL15, TNFRSF10B, TNFRSF14, VIM	CADM1, CD48, CD70, CD80, CD86, CSF2, IL18, MICB, PCNA, RAET1E, RAET1L, SELL, SLAMF6, SLAMF7, ULBP1,	–	PVRL2, CEACAM5, CDH1
Cluster 2	CFP, CLEC2B, CSF1, CSF3, HLA-E, HSPG2, IL15, IL2, MICA, RAET1G, TNFRSF10B, TNFRSF14, ULBP3, VIM,	CADM1, CD48, CD80, CD86, CSF2, IL18, MICB, PCNA, RAET1L, SELL, SLAMF6, SLAMF7, ULBP1	–	PVRL2, CEACAM5, CDH1
Cluster 3	CLEC2B, HLA-E, IL15, MICA, PDCD1LG2, TNFRSF14, VIM	CADM1, CEACAM1, PCNA, RAET1E, SELL, ULBP1	–	CEACAM1, PVRL2
Cluster 4	CFP, CLEC2B, CSF1, CSF3, HLA-E, IL15, MICA, TNFRSF10B, TNFRSF14, ULBP3, VIM	CADM1, CD48, CD80, CD86, CSF2, IL18, MICB, PCNA, RAET1L, SELL, SLAMF6, SLAMF7, ULBP1	–	PVRL2, CEACAM5, CDH1