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. 2020 Nov 27;10:34. doi: 10.1186/s13395-020-00252-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Ablation of CD82 in dystrophic muscle leads to worsened skeletal muscle phenotype. H&E images of the quadriceps muscles from mdx^5cv (a, b) and from CD82^−/−:mdx^5cv mice (d, e). Images were taken from tissues at 2 months (a, d) and 1 year (b, e) of age. c Comparisons of myofiber size using ANOVA shows significantly smaller myofibers in both strains of dystrophic mice compared to CD82^−/− mice, with CD82^−/−:mdx^5cv myofibers being the smallest. f Quantification of fibrosis at 2 months and 1 year of age shows increased presence of fibrotic tissue in young CD82^−/−:mdx^5cv compared to control mdx^5cv mice. Examples of images used in quantification are shown in Supplementary Figure 4F, G. g Distribution plots of myofiber size show significantly smaller myofibers in CD82^−/−:mdx^5cv compared to control mdx^5cv and CD82^−/− muscles. h Isometric force analysis following serial eccentric contractions demonstrated significantly decreased muscle force production after each contraction in CD82^−/−:mdx^5cv compared to control mdx^5cv mice. N = 6/group (**p ≤ 0.01; ***p < 0.001; ****p < 0.0001). Scale bars: 100 μm