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. 2020 Oct 26;12(11):3123. doi: 10.3390/cancers12113123

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combination treatment with irreversible electroporation (IRE) and STING agonist remodels the composition of immune cells in the tumor microenvironment (TME). Intratumoral CD45⁺ immune cells were analyzed by flow cytometry (* p < 0.05). (a) Representative flow cytometric plot and comparisons of CD86⁺CD11c⁺ activated DCs. (b) Representative flow cytometric plot and comparisons of the cell numbers of CD8⁺ T cells and CD4⁺ T cells (* p < 0.05). (c) Representative flow cytometric plot and comparisons of CD11b⁺F4/80⁺iNOS⁺ M1-like macrophages, CD11b⁺F4/80⁺Arg1⁺ M2-like macrophages, and M1/M2 ratio (* p < 0.05). Pooled data from two independent experiments with n = 5 per group. Values are mean ± SD. Two-tailed Student t test.