Figure A1.

(a) Extracted ion electropherograms for multiplexed analyses of salicyluric acid (SU) and creatinine simultaneously by multisegmented injection-capillary electrophoresis-mass spectrometry (MSI-CE-MS) under negative ion mode conditions, which were confirmed by their accurate mass and co-migration after spiking urine samples with authentic standards. (b) SU analysis of 17 patients with platelets not inhibited by 81 mg ASA and 12 controls not taking 81 mg ASA. (c) Concentration distributions for SU normalized to creatinine (µmol/mmol) in 17 patients with platelets not inhibited by 81 mg ASA and 12 controls not taking 81 mg ASA. Significant difference of SU levels between compliant and non-compliant patients is represented by (*) with p < 0.05.