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. 2020 Oct 28;13(11):348. doi: 10.3390/ph13110348

Figure 4.

Figure 4

Effect of individual treatment with doxorubicin (15 mg/kg; i.p.), pirfenidone (500 mg/kg; p.o.) or vitamin D (0.5 µg/kg; i.p.) and their combinations on the cardiac expression of α-SMA in EAC bearing mice on day 21. (A) A graph showing the density of immunostaining for α-SMA in experimental groups. (B) Photomicrographs showing cardiac expression of α-SMA. & p < 0.05 with respect to normal, * p < 0.05 with respect to control EAC, # p < 0.05 with respect to doxorubicin. $ p < 0.05 with respect to the co-therapy of doxorubicin, pirfenidone, and vitamin D (n = 5).