Table 3.
Global peak systolic strain amplitude and end-diastolic wall thickness of all patients with left ventricular hypertrophy (LVH), patients with LVH and confirmed etiology of hypertrophic cardiomyopathy (LVH+HCM+) and patients with LVH and a mimicking cardiomyopathy state (LVH+ HCM–).
| LVH+HCM+ | LVH+HCM– | |||||||
|---|---|---|---|---|---|---|---|---|
| All patients | HCM | All LVH+HCM– | CA | AFD | HTNcm | |||
| Global parameter | (N = 163) | (N = 85) | (N = 78) | (N = 18) | (N = 30) | (N = 30) | p-Value | AUC (95% CI) |
| Circumferential | ||||||||
| Subendocardium (%) | −17.1 ± 3.9 | −17.8 ± 3.7 | −16.3 ± 4.0* | −14.2 ± 5.9*** | −16.5 ± 2.6 | −17.2 ± 3.5 | <0.001 | 0.62 (0.54–0.71) |
| Subepicardium (%) | −6.8 ± 1.9 | −6.9 ± 1.9 | −6.8 ± 2.0 | −6.0 ± 2.2 | −7.1 ± 1.9 | −6.9 ± 1.9 | 0.29 | – |
| Transmural (%) | −11.2 ± 2.7 | 11.5 ± 2.6 | −11.0 ± 2.7 | −9.5 ± 3.7** | −11.4 ± 2.0 | −11.5 ± 2.5 | <0.05 | – |
| Longitudinal | ||||||||
| Subendocardium (%) | −15.0 ± 3.8 | −15.2 ± 3.9 | −14.7 ± 3.7 | −12.6 ± 5.1* | −15.3 ± 2.0 | −15.3 ± 3.8 | 0.06 | – |
| Subepicardium (%) | −6.6 ± 2.4 | −6.5 ± 2.3 | −6.7 ± 2.4 | −5.7 ± 2.3 | −7.3 ± 2.6 | −6.6 ± 2.1 | 0.1 | – |
| Transmural (%) | −10.3 ± 2.7 | −10.4 ± 2.8 | −10.2 ± 2.7 | −8.6 ± 3.3* | −11.0 ± 1.7 | −10.4 ± 2.7 | <0.05 | – |
| Global longitudinal shortening (%) | −13.0 ± 4.2 | −12.7 ± 4.2 | −13.4 ± 4.2 | −10.5 ± 5.0* | −14.9 ± 2.8* | −13.6 ± 4.0 | <0.005 | – |
| Radial | ||||||||
| Transmural (%) | 40.6 ± 19.6 | 37.4 ± 18.0 | 44.0 ± 20.9* | 29.5 ± 19.1 | 49.8 ± 17.1** | 46.8 ± 21.8* | <0.0005 | 0.60 (0.49–0.71) |
| Minimum principal | ||||||||
| Subendocardium (%) | −26.8 ± 4.7 | −27.8 ± 4.2 | −25.7 ± 5.1** | −22.2 ± 7.2**** | −27.0 ± 3.0 | −26.4 ± 4.3 | 0.0001 | 0.64 (0.52–0.76) |
| Subepicardium (%) | −18.5 ± 3.5 | −18.6 ± 3.1 | −18.3 ± 3.9 | −14.7 ± 4.6**** | −20.3 ± 2.6** | −18.5 ± 3.0 | 0.0001 | – |
| Transmural (%) | −22.8 ± 4.1 | −23.4 ± 3.6 | −22.2 ± 4.6 | −18.5 ± 6.2**** | −24.0 ± 2.7 | −22.6 ± 3.8 | <0.0001 | – |
| Maximum transmural | ||||||||
| Transmural (%) | 64.7 ± 24.5 | 63.2 ± 21.5 | 66.3 ± 27.6 | 46.1 ± 26.2** | 77.0 ± 21.6** | 67.8 ± 27.8 | <0.0005 | – |
| Thickness (mm) | 10.3 ± 2.5 | 11.3 ± 2.3 | 9.1 ± 2.1**** | 10.7 ± 2.7 | 8.1 ± 1.9**** | 9.3 ± 1.2**** | <0.0001 | 0.75 (0.71–0.80) |
AFD, Anderson-Fabry Disease; CA, cardiac amyloidosis; CI, confidence interval; HCM, hypertrophic cardiomyopathy; HTNcm, hypertensive hypertrophy; LVH, left-ventricular hypertrophy.
Vs. HCM:
*
<0.05.
**
<0.01.
***
<0.001.
****
<0.0001.
Bold values are used for specific headers or p-Values lower than 0.05 (i.e. statistical significance).