Figure 5.

Concentration-dependent reduction of OGG1 incisions by TH5487. (a,b) Reduced nuclear γH2AX intensity in U2OS cells treated with (a) KBrO₃ or (b) menadione and increasing concentrations of TH5487 for 1 h. (c,d) Mean values of (a) and (b). Scatterplots show data of at least 1000 (control) or 3300 (all other conditions) cells. Data are presented as median (a,b) and mean (c,d) ± SEM of two independent experiments with two technical repeats each. Statistical significance was determined using unpaired two-sided t-tests (** P < 0.01, **** P < 0.0001).