TABLE 3.

List of probable DR associated genes.

Categories		Genes
Hub genes		FN1 (Fibronectin 1), IL6 (Interleukin 6), COL1A2 (Collagen Type I Alpha 2 Chain), COL4A1 (Collagen Type IV Alpha 1 Chain), COL4A2 (Collagen Type IV Alpha 2 Chain), SPARC (Secreted Protein Acidic And Cysteine Rich), MMP9 (Matrix Metallopeptidase 9)
Early genes	Upregulated and hypomethylated	NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4), ROCK2 (Rho Associated Coiled-Coil Containing Protein Kinase 2), HTATIP2 (HIV-1 Tat Interactive Protein 2), UHRF1 (Ubiquitin Like With PHD And Ring Finger Domains 1), NTM (Neurotrimin)
	Downregulated and hypermethylated	MAPT (Microtubule Associated Protein Tau), FAM69C (Family With Sequence Similarity 69 Member C), FHOD3 (Formin Homology 2 Domain Containing 3), IGSF21 (Immunoglobin Superfamily Member 21)

Hub genes: potential candidate genes of DR which possess large number of interaction. Early genes: genes showing altered expression and methylation pattern during an early stage of DR.