Table 1.
Eligible studies for the risk of endometrial cancer and HIF-1α expression.
| Author | Reference | Time | Country | Ethnicity | Method | Cancer type | Histology | Normal tissue | Cancer tissue | Cut-off value | NOS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HIF-1α - | HIF-1α + | HIF-1α - | HIF-1α + | ||||||||||
| Feng | (20) | 2006 | China | Asians | IHC | EEC | Tissue | 15 | 0 | 21 | 29 | 0% | 6 |
| Wang | (21) | 2007 | China | Asians | IHC | EEC | Tissue | 11 | 3 | 16 | 28 | 10% | 6 |
| Horree | (22) | 2007 | Netherlands | Caucasians | IHC | EEC | Tissue | 17 | 0 | 5 | 34 | 5% | 7 |
| Zhang | (23) | 2010 | China | Asians | IHC | EEC | Tissue | 16 | 1 | 9 | 30 | 5% | 6 |
| Feng | (24) | 2013 | China | Asians | IHC | EEC | Tissue | 26 | 9 | 43 | 81 | 0% | 6 |
| Chen | (25) | 2015 | China | Asians | IHC | EEC | Tissue | 19 | 4 | 23 | 35 | 0% | 6 |
| Wu | (26) | 2016 | China | Asians | IHC | EEC | Tissue | 37 | 3 | 24 | 41 | 5% | 6 |
| Zhu | (27) | 2019 | China | Asians | IHC | EEC | Tissue | 25 | 5 | 9 | 41 | 0% | 6 |
| Sun | (28) | 2019 | China | Asians | IHC | EEC | Tissue | 114 | 14 | 32 | 96 | NR | 6 |
IHC, immunohistochemistry; EEC, endometrioid endometrial carcinoma.