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. 2020 Nov 5;7:588761. doi: 10.3389/fcvm.2020.588761

Table 3.

Adjusted hazard ratios and 95% confidence interval for Hb or RBC by quintiles on outcomes.

Hb p for trenda
Q1 Q2 Q3 Q4 Q5
n = 85 n = 73 n = 85 n = 76 n = 72
Median g/dl 10.40 11.80 12.80 13.70 14.90
All-cause mortalityb 5.64 (1.89–16.87) 1.83 (0.55–6.14) 1.44 (0.42–4.96) 2.91 (0.93–9.09) 1 (reference) 0.001
MACEc 6.15 (2.33–16.2) 2.86 (0.99–8.26) 1.39 (0.44–4.39) 3.28 (1.19–9.08) 1 (reference) 0.000
RBC p for trenda
Q1 Q2 Q3 Q4 Q5
n = 81 n = 76 n = 84 n = 73 n = 77
Median ×1012/L 3.45 3.89 4.23 4.52 4.96
All-cause mortalityb 3.0 (1.26–7.17) 1.48 (0.56–3.92) 0.82 (0.30–2.28) 1.00 (0.35–2.28) 1 (reference) 0.002
MACEc 2.70 (1.28–5.68) 1.36 (0.58–3.22) 0.77 (0.31–1.90) 0.79 (0.31–2.01) 1 (reference) 0.001

HRs and 95% CIs were calculated by Cox proportional-hazards regression models using the forward conditional method.

HRs, hazard ratios; COPD, chronic obstructive pulmonary disease; LDL-C, low-density lipoprotein-cholesterol; Hb, hemoglobin; Q, quintiles; RBC, red blood cell; MACE, major adverse cardiovascular events (a composite of all-cause death, recurrent rupture, and secondary procedure).

a

p for trend was calculated by entering the median value of each category of Hb and RBC quintiles.

b

Adjusted for age, COPD, hematocrit, cystatin C, urea nitrogen, and LDL-C.

c

Adjusted for age, COPD, hematocrit, cystatin C, urea nitrogen, creatinine, total cholesterol, and LDL-C.