Table 1.
Key genetic attributes of patient derived xenographs (PDX) cell lines.
Method | Mayo Sarkaria qMS-PCR | MD Anderson CLIA qMS-PCR | Sanger Sequencing | ||
---|---|---|---|---|---|
GBM | MGMT METHYLATION | MGMT METHYLATION | TERT | IDH1 | IDH2 |
6 | U | Indeterminate | C228T | wt | wt |
12 | M | M | C250T | wt | wt |
43 | U | M | C228T | wt | wt |
Cell lines used in experiments are all IDH1/2 wildtype. They have two distinct TERT mutations. U = unmethylated, M = methylated.