Table 1.
Univariable and multivariable Cox models of FAP intensity and CD8a density predicting the overall survival of colon cancer patients in the U-CAN cohort.
| Cox Regression Analysis | Univariable Cox Model | Multivariable Cox Model | ||||||
|---|---|---|---|---|---|---|---|---|
| Covariates | HR | 95.0% CI for HR | p-Value | HR | 95.0% CI for HR | p-Value | ||
| Lower | Upper | Lower | Upper | |||||
| FAP intensity TC (high vs. low) | 0.545 | 0.346 | 0.859 | 0.009 ** | 0.539 | 0.335 | 0.868 | 0.011 * |
| CD8a density TC (high vs. low) | 0.651 | 0.440 | 0.963 | 0.032 * | 0.694 | 0.452 | 1.066 | 0.095 |
| Age (≥66 years or <66) |
1.786 | 1.116 | 2.856 | 0.016 * | 1.243 | 0.728 | 2.122 | 0.425 |
| Stage (III_IV vs. I_II) |
2.941 | 1.905 | 4.540 | 0.000 *** | 6.425 | 3.915 | 10.545 | 0.000 *** |
| MMR status (MSS vs. MSI) |
1.405 | 0.835 | 2.365 | 0.200 | 1.139 | 0.640 | 2.027 | 0.659 |
| Adjuvant treatment (Yes vs. No) |
0.515 | 0.332 | 0.797 | 0.003 ** | 0.220 | 0.129 | 0.375 | 0.000 *** |
| Location (Right or Left) |
1.075 | 0.734 | 1.575 | 0.709 | 1.202 | 0.790 | 1.829 | 0.391 |
| Gender (male vs. female) |
1.053 | 0.719 | 1.541 | 0.791 | 0.738 | 0.489 | 1.115 | 0.149 |
* p < 0.05, ** p < 0.01, *** p < 0.001; HR (Hazard Ratio); TC (Tumor Center); MMR (Mismatch repair).