Table 2.
Univariable and multivariable Cox models of FAP intensity and CD8a density predicting the overall survival of colon cancer patients in the “Nordic adjuvant randomized clinical trial”.
| Cox Regression Analysis | Univariable Cox Model | Multivariable Cox Model | ||||||
|---|---|---|---|---|---|---|---|---|
| Covariates | HR | 95.0% CI for HR | p-Value | HR | 95.0% CI for HR | p-Value | ||
| Lower | Upper | Lower | Upper | |||||
| FAP intensity TC (high vs. low) |
0.753 | 0.524 | 1.080 | 0.123 | 0.629 | 0.415 | 0.952 | 0.029 * |
| CD8a density TC (high vs. low) |
0.794 | 0.503 | 1.254 | 0.323 | 1.050 | 0.604 | 1.824 | 0.863 |
| Age (≥66 years or <66) |
1.280 | 0.882 | 1.857 | 0.194 | 1.323 | 0.877 | 1.995 | 0.182 |
| Stage (III_IV vs. I_II) |
2.067 | 1.421 | 3.008 | 0.000 *** | 2.242 | 1.478 | 3.402 | 0.000 *** |
| MMR status (MSS vs. MSI) |
2.190 | 1.173 | 4.088 | 0.014 * | 2.294 | 1.182 | 4.455 | 0.014 * |
| Adjuvant treatment (Yes vs. No) | 1.075 | 0.750 | 1.540 | 0.694 | 0.980 | 0.660 | 1.455 | 0.920 |
| Location (Right or Left) |
0.828 | 0.578 | 1.186 | 0.302 | 1.199 | 0.795 | 1.808 | 0.388 |
| Differentiation grade (Low vs. High) |
1.201 | 0.780 | 1.849 | 0.406 | 1.244 | 0.752 | 2.056 | 0.395 |
| Gender (male vs. female) |
1.188 | 0.826 | 1.709 | 0.352 | 1.273 | 0.849 | 1.911 | 0.243 |
* p < 0.05, *** p < 0.001; HR (Hazard Ratio); TC (Tumor Center); MMR (Mismatch repair).