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. 2020 Oct 28;12(11):3169. doi: 10.3390/cancers12113169

Figure 1.

Figure 1

Id1 expression inversely correlates with the mRNA expression levels of several markers related to immune response. (A) Pearson correlation coefficients (green) and p-values (red) between Id1 mRNA expression levels and different genes associated with the immune system in LUAD patients. (B) Western blot for detection of Id1 protein in human H1792 cells infected with doxycycline-inducible shRNA lentiviral particles that target Id1, in comparison with the same cell lines infected with a control i-GFPsh. (C) Flow cytometry analysis showed a statistically significant increase in PD-L1 expression after exposure to IFN-γ for 24 hours when human H1792 tumor cells had Id1 inhibited (Median of peak value: H1792 +IFN-γ: i-GFPsh 610.0 [579.5–641.5], i-Id1sh 790.5 [734.0–874.5], p = 0.0022). The data are reported as the median with the interquartile range. ** p < 0.01.