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. 2020 Oct 28;12(11):3169. doi: 10.3390/cancers12113169

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combined inhibition of Id1 and anti-PD-1 therapy promotes the tumor infiltration of different immune cell populations. (A) HC and quantification of CD3 expression in representative sections of tumors belonging to group of mice with extreme phenotypes [Id1+/+/DPBS (pLKO-sc LLC cells), Id1+/+/anti-PD-1 (pLKO-sc LLC cells), Id1-/-/DPBS (Id1sh LLC cells) and Id1-/-/anti-PD-1 (Id1sh LLC cells]. (B) IHC and quantification of CD8 expression in representative sections of the same tumors as in A. (C) IHC and quantification of CD4 expression in representative sections of the same tumors as in A. (D) IHC and quantification of FOXP3 expression in representative sections of the same tumors as in A. The data are reported as the median with the interquartile range or mean ± SD. ** p < 0.01, *** p < 0.001, n.s. (not significant). Scale bar, 30 µm.