Table 2.

The most densely interconnected regions of the protein-protein interactions (PPI) network are categorized by MCODE from our identified associated genes between Obesity, T1D, T2D, and MODY.

Cluster	Score (Density * # Nodes)	Nodes	Edges	Nodes IDs
1	33.61	83	1378	C3, TNC, APOA2, MTNR1A, MTNR1B, CXCL5, SERPINA1, AHSG, ALB, GAST, BMP4, SPP1, SST, APOA5, PYY, F5, FGF23, IGFBP3, PPY, CCK, TRH, CCKAR, GNRH1, GCG, GRP, OPRM1, HCRT, GPR39, GHSR, IGFBP7, DRD4, POMC, CX3CR1, ADRA2A, APOA1, TAC1, NTS, GAL, ADRA2B, TIMP1, HTR1A, CCR2, APOB, FGA, BDKRB2, GNAI1, KNG1, PNPLA2, APOE, APLNR, APLN, IGFBP1, CASR, AGTR1, CXCL8, EDN1, MLN, EDNRA, PROC, OXT, PCSK9, AGT, CNR1, DRD2, PIK3R1, PIK3CA, F2, CXCR4, SERPINC1, IGFBP5, CCL5, APP, HTR2A, CCR5, CSF1, CNR2, NPY, GCGR, CP, TF, IL6, CST3, ADORA1
2	16.788	34	277	GIP, PROS1, FGB, TGFB1, CLU, ADRB3, IGF1, MC4R, VWF, A2M, CALCA, PTH, IAPP, HGF, CGA, RAMP1, ADRB1, DRD1, F13A1, SERPINF2, SPARC, TSHR, GNAS, GLP1R, THBS1, GPBAR1, ADRB2, SERPINE1, ADM, CRH, MC3R, GHRH, IGF2, VEGFA
3	6.783	24	78	SH3GL2, INPPL1, TIMP2, CTSS, IL5, LTF, SHC1, PIK3C2A, IRS1, TFRC, MMP8, PTPN1, HP, B2M, LDLR, PRKCZ, MMP9, INS, WNT5A, FTH1, INSR, IGF1R, IGF2R, RPS27A

* Network computation based on node score cutoff and K-core; Cluster seeds are in bold.