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5-FU (A) and DEX (B) accumulation in different skin layers and receptor media when delivered by MSN-NH2 and free in gel. Data are represented as mean ± SD (n = 3). Statistical significance was obtained with p-values ≤ 0.05, where * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001.
