Table 1.

Reductive iron acquisition system in Saccharomyces cerevisiae and pathogenic Mucoralean species.

Component	Species	Gene	Functions	Ref
Ferric reductases	Saccharomyces cerevisiae	FRE1, FRE2	Ferric iron reduction at the cell surface	[3,36,65]
	Rhizopus spp.	FRE (homolog)	Putative protein—ferric iron reduction at the cell surface	[48,66]
	Mucor circinelloides	FRE (homolog)	Putative protein—ferric iron reduction at the cell surface	[47,67]
	Lichtheimia corymbifera	FRE5 (homolog)–three copies	Putative protein—ferric iron reduction at the cell surface	[49]
Multicopper ferroxidase	S. cerevisiae	FET3	Multicopper-oxidase Ferrous iron oxidation and high-affinity uptake coupled with Ftr1 (permease)	[3,55,65,68]
	Rhizopus spp.	FET3 homolog	Putative multicopper oxidase	[48]
	M. circinelloides	FETA, FETB, FETC	Ferrous iron oxidation and high-affinity iron uptake	[47]
	L. corymbifera	FET3/5 homolog–three copies	Putative multicopper oxidase	[49]
Iron permease	S. cerevisiae	FTR1	High-affinity iron uptake, coupled with FET3 (multicopper oxidase)	[3,59,68,69,70]
	Rhizopus spp.	FTR1	High affinity iron permease	[65,71,72]
	M. circinelloides	FTR1 (homolog)	Putative iron permease	[47,73]
	L. corymbifera	FTR1 (homolog)—four copies	Putative iron permease	[49]