Figure 7.
Immunohistochemical staining of renal tissues with HMBG1, NF-κB, and TNF-α antibodies after cisplatin induction of kidney injury. Pre-treatment with linalool (50 and 100 mg/kg) for 14 days diminished the number of positive cells containing HMBG1, NF-κB, and TNF-α. All values are expressed as mean ± SD (n = 3). # denotes statistically significant from the normal control group, * indicates statistically significant from the cisplatin-only group, and @ represents statistically significant from the cisplatin + linalool 50 mg/kg group (p < 0.05) using one-way ANOVA followed by Tukey’s post-hoc test.