Table 2.
Effects of linalool and cisplatin on renal function markers in rats.
| Treated Groups | Mortality Rate | Body Weight (gm) | Kidney Index | Blood Urea Nitrogen (BUN) (mg/dL) |
Creatinine (mg/dL) |
|
|---|---|---|---|---|---|---|
| Before Treatment | After Treatment | |||||
| Normal | 0/10 | 190 ±8.68 | 220 ±10.75 | 0.71 ± 0.05 | 35.75 ± 3.7 | 0.38 ± 0.12 |
| Linalool | 0/10 | 200 ±11.46 | 240 ±12.47 | 0.74 ± 0.12 | 37.75 ± 2.82 | 0.46 ± 0.85 |
| Cisplatin | 2/10 | 189.42 ± 9.42 | 150.42 ± 7.46 # | 0.94 ± 0.05 # | 174.33 ± 14.50 # | 3.21 ± 0.16 # |
| Cisplatin + linalool (50 mg/kg) | 0/10 | 196.00 ± 14.75 | 185.00 ± 12.76 | 0.57 ± 0.10 * | 70.83 ± 2.40 * | 1. 53 ± 0.05 * |
| Cisplatin + linalool (100 mg/kg) | 0/10 | 184.00 ± 13.5 | 178.00 ± 13.7 | 0.55 ± 0.08 * | 67.83 ± 2.40 * | 1.46 ± 0.05 * |
All values are expressed as mean ± SD. #, statistically significant from normal control group; *, statistically significant from cisplatin-only group (p < 0.05 using one-way ANOVA followed by Tukey’s test as a post-hoc analysis.