Table 1.
Hydrogenation of BE186 and BE503 using different ratios of IPA (wt%) in solvent mixtures.
| Entry | Solvent | Concentration (wt%) | Time (h) | Yield (%) |
|---|---|---|---|---|
| 1 * | Solvent 3 (3 wt% H2O, 7 wt% IPA, 90 wt% EA) |
50 | 0.5 | 62.4 |
| 2 * | Solvent 5 (3 wt% H2O, 27 wt% IPA, 70 wt% EA) |
50 | 0.5 | 63.0 |
| 3 * | Solvent 6 (3 wt% H2O, 47 wt% IPA, 50 wt% EA) |
50 | 0.5 | 59.7 |
| 4 * | Solvent 7 (3 wt% H2O, 67 wt% IPA, 30 wt% EA) |
50 | 0.5 | 58.2 |
| 5 * | Solvent 8 (10 wt% H2O, 20 wt% IPA, 70 wt% EA) |
50 | 0.5 | 65.9 |
| 6 ** | Solvent 8 (10 wt% H2O, 20 wt% IPA, 70 wt% EA) |
30 | 2 | 70.8 |
| 7 ** | EA | 30 | 2 | 54.2 |
| 8 ** | Solvent G (3 wt% H2O, 97 wt% EA) |
30 | 2 | 64.0 |
Note: 2 g BPAER (* BE186, ** BE503), 2 g solvent for entries 1–5, 4.66 g solvent for entries 6–8, 0.05 g Rh5/VulcanXC72-polyol, H2 pressure of 1000 psi, 40 °C, concentration: Wreactant/Wreactant+solvent, RSD for hydrogenation yield ≤ 2%.