Table 1.
Hepatocellular carcinoma (HCC) animal models used in angiopoietin-related research to date.
| Experimental HCC Animal Model | Ref. |
|---|---|
| Diethylnitrosamine-induced HCC rat model | [56] |
| Diethylnitrosamine-induced HCC mouse model | [31] |
| Nonalcoholic steatohepatitis-induced HCC mouse model | [38] |
| Subcutaneous syngeneic HCC mouse model (injection of MH134 cells in C3H mice) |
[30] |
| Subcutaneous syngeneic HCC mouse model (injection of Hepa1-6 cells in C57BL/6 mice) |
[48,49] |
| Orthotopic syngeneic HCC mouse model (injection of Hepa1-6 cells in C57BL/6 J mice) |
[48,49] |
| Murine subcutaneous xenograft model of human HCC (injection of BEL-7404 cells in BALB/c nude mice) |
[52] |
| Murine orthotopic xenograft model of human HCC (injection of VETC-2 cells in BALB/c nude mice) |
[49] |
| Highly metastatic murine orthotopic xenograft model of human HCC (implantation of metastatic tumor tissue of murine subcutaneous xenograft model of human HCC in BALB/c nude mice) |
[54] |