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. 2020 Oct 24;8(11):450. doi: 10.3390/biomedicines8110450

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Differentially expressed tRNAs in EVs derived from Ngfr^−/− and Sort1^−/− compared with EVs from WT Schwann cells. (a) Heatmap covering the most significantly changing tRNAs, with p-values (not multiple-testing corrected) below 0.05 in one or more of the pairwise comparisons. Top annotation shows Sort1^−/− in orange, Ngfr^−/− in yellow and control WT as blue. Shown are z scores of log2-transformed RPM values. (b) Volcano plot for EV tRNAs from Ngfr^−/− versus WT comparison and (c) Volcano plot for EV tRNAs from Sort1^−/− versus WT. Plotted are –log10(p-values) vs. −log2(fold change). Red means < 0.05 adjusted p-value. Vertical lines indicate +/− 1 log2(fold change). The names for the 10 most significant tRNA are indicated.