Table 3.
In vitro antileishmanial activity against intramacrophagic amastigotes of L. infantum and cytotoxicity against PMA-differentiated THP-1 (human acute monocytic leukemia cell line).
| Compd. |
L. infantum Amastigotes IC50a (µM) |
THP-1 CC50 a,b (µM) |
SI c |
|---|---|---|---|
| 1 | 3.49 ± 0.18 | 27.97 ± 8.00 | 8.0 |
| 14 | 2.13 ± 1.35 | 21.66 ± 8.83 | 10.2 |
| 17 | 2.70 ± 0.68 | 53.90 ± 3.98 | 20.0 |
| Lucanthone | 3.43 ± 0.93 | 15.17 ± 0.27 | 4.4 |
a Data are expressed as mean ± SD of three experiments in triplicate. b Compound concentration (µM) required to reduce the viability of PMA-differentiated THP-1 by 50%. c The selectivity index (SI) is expressed as the ratio between the CC50 value of each compound against THP-1 cell line and the IC50 against L. infantum amastigotes.