Table 1.
siRNA-based therapeutics under clinical investigation for cancer treatment.
| Name | Cancer Type | Target |
|---|---|---|
| ALN-VSP | Liver Cancer and metastases | VEGF gene, kinesin spindle (KSP) [30,31] |
| APN401 1 | Various solid tumors | CBLB protein [32] |
| Atu-027 | Advanced Solid Tumors/Pancreatic cancer | Protein Kinase N3 gene [30,31] |
| CALAA-01 | Solid Tumors | M2 subunit of ribonucleotide reductase (R2) [31,32] |
| DCR-MYC | Liver cancer, Multiple myeloma, Non-Hodgkin’s lymphoma, Pancreatic cancer, Solid tumors |
C-Myc [31] |
| EphA2 | Advanced or Recurrent Solid Tumors | EphA2 [31,32,33] |
| siG12D LODER | Advanced pancreatic cancer | KRAS G12D [31,32,33] |
| SPC2996 | Chronic Lymphocytic Leukemia | Bcl-2 gene [30] |
| TKM 080301 | Neuroendocrine tumors (NET) and adrenocortical carcinoma (ACC) tumors | Pololike kinase 1 (PLK1) [33] |
1 siRNA transfected peripheral blood mononuclear cells.