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. 2020 Oct 29;18(11):541. doi: 10.3390/md18110541

Figure 3.

Figure 3

Effect of the Penicillium purpurogenum extract on the development of Ehrlich’s solid tumor. (a) The kinetic of the paw volume inoculated with Ehrlich’s tumor followed by intraperitoneal treatment with phosphate buffer solution (CTL−), cyclophosphamide 25 mg/kg (CTL+), and extracts with a concentration of 4 mg/kg (EAE4), 20 mg/kg (EAE20), and 100 mg/kg (EAE10) at 24 h intervals, with the animals being euthanized on day 15. (b) The area under the curve (AUC) calculated from the volume growth kinetics. (c) The average weight of the paws with a tumor was determined in the groups after treatment. Values are expressed as the mean ± standard error of means (SEM) deviation and analyzed by analysis of variance (one-way or two-way ANOVA) with * p < 0.05, ** p < 0.005, and **** p < 0.0001 relative to the negative control (CTL−); # p < 0.05, ## p < 0.01 when compared to the positive control (CTL+); and Θ p < 0.05 shows a difference in tumor growth for the other groups; φ shows that, on the eighth day, only the extract inhibited tumor growth.