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. 2020 Oct 31;12(11):3217. doi: 10.3390/cancers12113217

Figure 2.

Figure 2

The E3 aptamer targets broadly across different PDX-derived cancer cells. Cancer cells were incubated with DL650-E3 aptamer or DL650-C36 control aptamer and analyzed, as described in Figure 1. The binding curves are the combination of three independent experiments, with the median fluorescent intensity (MFI) of the aptamer-treated samples normalized to the median fluorescent intensity of the cells alone signal. Flow cytometry analysis of E3 targeting to (a) the colorectal PDX-derived cell lines CRC051x, CRC119x, CRC240XIa, and CRC247XI; (b) the cholangiocarcinoma PDX-derived cell line CRC292XI; (c) the renal cancer cell line 13-789; and (d) the osteosarcoma cancer cell line 17-3X.