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. 2020 Oct 31;12(11):3217. doi: 10.3390/cancers12113217

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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E3 MMAE and MMAF induce cell death in a broad number of cancer cells. (a) Viability of MCF7 breast, Jurkat blood and U-118MG brain cancer and PANC-1, MIA PaCa-2 and BxPC-3 pancreatic cancer cells treated with MMAF-E3 and MMAF-C36. (b) Viability of MCF7 breast, Jurkat blood and A431 skin cancer and PANC-1, MIA PaCa-2 and BxPC-3 pancreatic cancer cells treated with MMAF-E3 and MMAF-C36. (c) Viability of MDA-MB-231 breast and SK-N-AS brain cancer cells treated with MMAE-E3 and MMAE-C36 or with MMAF-E3 and MMAF-C36. The MMAE-C36 and MMAF-C36 data for the pancreatic cancer cells is from [13]. Cells were incubated with increasing concentrations of ApTDCs and viability determined at 144 h.

E3 MMAE and MMAF induce cell death in a broad number of cancer cells. (a) Viability of MCF7 breast, Jurkat blood and U-118MG brain cancer and PANC-1, MIA PaCa-2 and BxPC-3 pancreatic cancer cells treated with MMAF-E3 and MMAF-C36. (b) Viability of MCF7 breast, Jurkat blood and A431 skin cancer and PANC-1, MIA PaCa-2 and BxPC-3 pancreatic cancer cells treated with MMAF-E3 and MMAF-C36. (c) Viability of MDA-MB-231 breast and SK-N-AS brain cancer cells treated with MMAE-E3 and MMAE-C36 or with MMAF-E3 and MMAF-C36. The MMAE-C36 and MMAF-C36 data for the pancreatic cancer cells is from [13]. Cells were incubated with increasing concentrations of ApTDCs and viability determined at 144 h.