Figure 5.

The Stab2/HARE CD has four potential endocytic targeting motifs. The 72 aa CD (Y²⁴⁸⁰–L²⁵⁵¹) next to the TMD contains four different AP-2/clathrin-mediated targeting motifs (boldface: M1-M4) that enable coated pit mediated endocytosis by both receptor isoforms, free or ligand-bound. Motifs in the top row (red) target HARE•HA complexes for endocytosis; M4 (black) is the only motif that does not mediate HA uptake. Motifs in the bottom row (blue) target HARE•Hep complexes for endocytosis; M2 (black) is the only motif that does not mediate Hep uptake. A tryptic peptide (underlined) contains phospho-Ser²⁴⁹⁷ (asterisk). Dot symbols (•) denote noncovalent bonding.