Table 1.
Summary of differentially expressed circRNAs evaluated in Pancreatic Ductal Adenocarcinoma (PDAC). * All studies evaluated PDAC patient samples except hsa_circ_100782 which was evaluated in PDAC cell lines alone.
| Author | Year | Cancer Type | circRNA | Expression in PDAC Samples | Association with Features of Malignancy Demonstrated |
|---|---|---|---|---|---|
| Chen G. at al. [78] * | 2017 | PDAC | hsa_circ_100782 | Upregulated | In vitro and in vivo |
| Yang F. et al. [79] | 2017 | PDAC | hsa_circ_0006988 | Upregulated | Clinical data |
| An Y. et. al. [80] | 2018 | PDAC | hsa_circ_0099999 (circZMYM2) |
Upregulated | In vitro and in vivo |
| Zhu P. et al. [81] | 2018 | PDAC | hsa_circ_0006215 | Upregulated | In vitro |
| Li J. et al. [82] | 2018 | PDAC | circ-IARS | Upregulated | In vitro, in vivo and clinical data |
| Li Z. et al. [47] | 2018 | PDAC | circ-PDE8A | Upregulated | In vitro, in vivo and clinical data |
| Jiang Y. et al. [83] | 2018 | PDAC | hsa_circ_0001649 | Downregulated | In vitro and clinical data |
| Qu S. et al. [46] | 2019 | PDAC | hsa_circ_0005397 (circ-RHOT1) |
Upregulated | In vitro |
| Xu Y. et al. [84] | 2019 | PDAC | hsa_circ_0030235 | Upregulated | In vitro and clinical data |
| Hao L. et al. [54] | 2019 | PDAC | hsa_circ_0007534 | Upregulated | In vitro, in vivo and clinical data |
| Liu L. et al. [85] | 2019 | PDAC | ciRS-7 (Cdr1as) | Upregulated | In vitro and clinical data |
| Yang J. et al. [86] | 2019 | PDAC | hsa_circ_0007334 | Upregulated | In vitro |
| Yao J. et al. [87] | 2019 | PDAC | circLDLRAD3 | Upregulated | In vitro and in vivo |
| Chen Y. et al. [88] | 2019 | PDAC | circASH2L | Upregulated | In vitro, in vivo and clinical data |
| Xing C. et al. [89] | 2019 | PDAC | circADAM9 | Upregulated | In vitro, in vivo and clinical data |
| Zhang X et al. [48] | 2020 | PDAC | hsa_circ_001653 | Upregulated | In vitro, in vivo and clinical data |
| Liu Y. et al. [90] | 2020 | PDAC | circHIPK3 | Upregulated | In vitro and in vivo |
| Wong C. et al. [91] | 2020 | PDAC | circFOXK2 | Upregulated | In vitro and in vivo |
| Guo X. et al. [92] | 2020 | PDAC | hsa_circ_0009065 (circBFAR) |
Upregulated | In vitro and in vivo |
| Kong Y. et al. [93] | 2020 | PDAC | hsa_circ_0086375 (circNFIB1) | Downregulated | In vitro, in vivo and clinical data |
| Guo W. et al. [94] | 2020 | PDAC | hsa_circ_0013912 | Upregulated | In vitro, in vivo and clinical data |
| Zhang X. et al. [95] | 2020 | PDAC | hsa_circ_001587 | Downregulated | In vitro, in vivo and clinical data |