Table 4.

Function of circRNAs in PDAC identified in animal studies. * All circRNAs were upregulated in PDAC, except for hsa_circ_0086375 (circNFIB1) and hsa_circ_001587, which were downregulated.

circRNA	Animal	Method	Findings
hsa_circ_100782	Nude mice	circRNA knockdown	Decreased tumour size
hsa_circ_0099999	Nude mice	circRNA knockdown	Decreased tumour size
circ-IARS	Nude mice	circRNA overexpression	Increased tumour size and metastatic disease
circ-PDE8A	Nude mice	circRNA overexpression	Increased peripheral blood exosomal GFP signals
hsa_circ_0007534	Nude mice	circRNA knockdown	Decreased tumour size
circ-LDLRAD3	Nude mice	circRNA knockdown	Decreased tumour size and weight
circASH2L	Nude mice	circRNA overexpression	Increased tumour size and metastatic disease
circADAM9	Nude mice	circRNA knockdown	Decreased tumour size and weight
hsa_circ_001653	Nude mice	circRNA knockdown	Decreased tumour size and weight
circHIPK3	Nude mice	circRNA knockdown	Decreased tumour size and weight
circFOXK2	Nude mice	circRNA knockdown	Decreased tumour size and metastasis
hsa_circ_0009065 (circBFAR)	Nude mice	circRNA overexpression	Increased tumour size
hsa_circ_0086375 (circNFIB1)	Nude mice	circRNA knockdown *	Increased lymph node metastasis
hsa_circ_0013912	Nude mice	circRNA knockdown	Decreased tumour size and weight
hsa_circ_001587	Nude mice	circRNA overexpression *	Decreased tumour size and weight
		circRNA knockdown *	Increased tumour size and weight