Table 5.
Summary table of clinical characteristics seen with differential circRNA expression in PDAC. “↑” indicates an increase; “↓” indicates a decrease; “←→” indicates no significant difference demonstrated; and “−“ indicates this measure was not reported.
| circRNA | Direction of Dysregulation | Sample Assessed | Tumour Size | Duodenal Invasion | Neural Invasion | Lymphatic Spread | Vascular Spread | Metastatic Disease | Stage (TNM) | Differentiation Grade | Survival Time |
|---|---|---|---|---|---|---|---|---|---|---|---|
| hsa_circ_0006988 | Upregulated | Tissue | ←→ | − | − | ↑ | ↑ | ←→ | ←→ | − | − |
| hsa_circ_0006988 | Upregulated | Plasma | ←→ | − | − | ↑ | ↑ | ←→ | − | − | − |
| circ-IARS | Upregulated | Tissue | ←→ | ←→ | ↑ | ←→ | ↑ | ↑ | ↑ | − | ↓ |
| circ-PDE8A | Upregulated | Tissue | ←→ | ←→ | ←→ | ↑ | ←→ | ←→ | ↑ | ←→ | ↓ |
| circ-PDE8A | Upregulated | Plasma exosome | ←→ | ↑ | ←→ | ←→ | ↑ | ↑ | ↑ | ←→ | ↓ |
| hsa_circ_0001649 | Downregulated | Tissue | − | − | − | ←→ | − | − | ↑ | ↓ | ↓ |
| hsa_circ_0030235 | Upregulated | Tissue | − | − | − | ↑ | − | − | ↑ | ←→ | ↓ |
| hsa_circ_0007534 | Upregulated | Tissue | − | − | − | ↑ | − | − | ↑ | ←→ | − |
| ciRS-7 (Cdr1as) | Upregulated | Tissue | ←→ | − | − | ↑ | ↑ | − | − | − | − |
| circASH2L | Upregulated | Tissue | ←→ | ←→ | ←→ | ↑ | ←→ | ←→ | ↑ | ←→ | ↓ |
| circADAM9 | Upregulated | Tissue | − | − | − | ↑ | − | − | ↑ | − | ↓ |
| hsa_circ_001653 | Upregulated | Tissue | − | − | − | − | − | − | − | − | ↓ |
| hsa_circ_0009065 (circBFAR) |
Upregulated | Tissue | ←→ | − | − | ←→ | − | − | ↑ | ←→ | ↓ |
| hsa_circ_0086375 (circNFIB1) | Downregulated | Tissue | ←→ | − | − | ↑ | − | − | ↑ | ←→ | ↓ |
| hsa_circ_0013912 | Upregulated | Tissue | ←→ | − | − | ↑ | − | − | ↑ | − | − |
| hsa_circ_0086375 (circNFIB1) | Downregulated | Tissue | − | − | − | ↑ | − | − | − | ↑ | ↓ |