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. 2020 Nov 4;9(11):913. doi: 10.3390/pathogens9110913

Table 4.

Independent predictors of ICU mortality according to multivariate logistic regression analysis.

Variables Odds Ratio (95% CI) p Value
Model 1
APACHE II score at ICU admission 1.16 (0.98–1.38) 0.08
NLR 1.07 (1.02–1.14) 0.01
Platelet 1.00 (0.99–1.01) 0.46
Procalcitonin 1.95 (0.10–39.65) 0.66
Model 2
NLR level p for trend
Low (≤16.2) Reference 0.009
Medium (16.2–24.0) 15.41 (1.20, 197.32)
High (≥24.0) 20.83 (2.06, 210.95)
Model 3
APACHE II score at ICU admission (per point) 1.25 (1.05, 1.49) 0.01
Neutrophil count 1.16 (0.99–1.36) 0.07
PLR 1.001 (1.00–1.003) 0.08
Procalcitonin 0.53 (0.04–7.14) 0.64
Model 4
APACHE II score at ICU admission 1.11 (0.91–1.36) 0.32
NLR 1.07 (1.002–1.14) 0.04
Platelet 0.997 (0.99–1.01) 0.66
Procalcitonin 3.07 (0.06–170.6) 0.58
Bacterial infection 19.16 (1.96–187.3) 0.01

Model 1 chose ICU mortality as the dependent variable and was adjusted for APACHE II score at ICU admission, NLR, platelet count, and procalcitonin level. Model 2 chose ICU mortality as the dependent variable and was adjusted for APACHE II score at ICU admission, NLR (as a categorical variable), platelet count, and procalcitonin. Model 3 chose ICU mortality as the dependent variable and was adjusted for APACHE II score at ICU admission, neutrophil count, PLR, and procalcitonin level. Model 4 chose ICU mortality as the dependent variable and was adjusted for APACHE II score at ICU admission, NLR, platelet count, procalcitonin level, and bacterial infection. As the APACHE II score has repeated items of PaO2/FiO2 ratio and white blood cell count, APACHE II score was added only to the multivariate analysis. APACHE II, Acute Physiology and Chronic Health Evaluation II; CI, confidence interval; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.