Table 2.
DUBs associated with stemness signaling pathways.
| Signaling Pathway | CSC Fate | DUBs Involved | Functions |
|---|---|---|---|
| Hedgehog | Breast glioblastoma adenocarcinoma |
USP21 USP 8 |
Cell growth, cell specialization, patterning of the body |
| Wnt signaling pathway | Glioma | USP4 USP8 |
Embryonic development |
| Notch | Ovarian | EIF3f USP9X USP12 CYLD USP28 |
Cell–cell communication |
| Hippo | Osteosarcoma | USP9X USP11 |
Modulates cell proliferation |
| TGF/BMP | Breast | OTUB1 USP9X | Embryonal development, cellular differentiation, hormone secretion, immune function |