Symbol	Description	Possible Values	Location
k	AE type	Integer from 1 up to 827
g	AE grade	1, 2, 3, 4, 5
t	Time (treatment cycle) of AE occurrence	Integer from 1 up to the maximum number of cycles
$Y_{kg}$	AE occurrence indicator	1 = yes, 0 = no	Equation (1)
$w_{kg}$	Weight for AE type (k) and grade (g)	Numerical value ≥0
$u_t$	Weight for time (t)	Numerical value ≥0
$B\left(t\right)$	AE burden at time t	Numerical value ≥0	Equation (2)
TB	Overall AE burden score	Numerical value ≥0	Equation (3)