Figure 1.

Shared identity-by-descent (IBD) haplotype between all carriers of the CHEK2 variant c.349A>G. (A). Shared IBD segments by populations: Australia, Portugal, Scandinavia (Denmark and Sweden), Spain, Western/Central Europe populations (Belgium, France, Germany and Netherlands), UK, and U.S. (B) Characterisation of IBD core segment shared by all carriers (≈0.4 Mb in detail, represented in light orange in Figure 1A). (C) Median joining phylogenetic tree of the largest shared haplotype region flanking the CHEK2 variant c.349A>G between all carriers (indicated in light grey in Figure 1A).