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. 2020 Nov 4;9(11):2414. doi: 10.3390/cells9112414

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scoring of chronic constriction injury (CCI)-induced nerve injury in the hind paw. Nav1.8-tdTomato nerve fibers were observed using a fluorescent microscope. (A) The underside of the hind paw was divided into 10 regions (eight in the five toes, two in the palm of the paw), as indicated by different colors. One point was scored for each area that exhibited a high degree of innervation. Examples of (B) a healthy hind paw scoring 10 points; (C) a moderately injured hind paw scoring 5 points; (D) a severely injured hind paw scoring only 1 point. Arrows indicate nerve fibers. (E) A higher-magnification view showing the nerve fibers remaining in the regions of interest (ROI) indicated in (D). Scale bars: 1000 μm (B–D) or 50 μm (E).