Table 1.
Dysregulated miRNAs in thyroid cancer.
| miRNA | Alteration | Mechanism | Thyroid Cancer Type | Sample | Ref. |
|---|---|---|---|---|---|
| miR-146a/b-5p | ↑ | ↓ RAR-β | PTC | Cell line and tissue | [52] |
| miR-155 | ↓ SOCS1 | ATC | [53] | ||
| miR-21 | ↓ VHL → ↑ N-cadherin and vimentin | PTC | [54] | ||
| miR-574-5p | ↓ SCAI → ↑ β-catenin | [55] | |||
| miR-625-3p | ↑ Bcl-2, ↓ Bax, and cleaved caspase 3/9 | [56] | |||
| miR-96 | ↓ FOXO1 → ↓ Bim | Cell line | [57] | ||
| Let-7a | ↓ | Not known | Not known | Tissue | [58] |
| miR-125a-5p | ↑ CD147 → ↓ glucose metabolism | PTC, FTC, MTC and ATC | Cell line and tissue | [59] | |
| miR-1266 | ↑ FGFR2 | PTC | [60] | ||
| miR-141-3p | ↑ YY1 | [61] | |||
| miR-144 | ↑ TGF-α | ATC | [62] | ||
| miR-148a | ↑ INO80 | ATC cancer stem cells | [63] | ||
| miR-150 | ↑ROCK1 | PTC | Cell line and tissue | [64] | |
| miR-195 | ↑ CCND1 and FGF2 → ↑ β-catenin, c-Myc, cyclin D1 and MMP-13 | [65] | |||
| miR-199b-5p | ↑ STON2 → ↑ N-cadherin and fibronectin | [66] | |||
| miR-375 | ↑ ERBB2 | [57] | |||
| miR-497 | ↑ AKT3 | [67] | |||
| miR-524-5p | ↑ FOXE1 and ITGA3 | [68] | |||
| miR-7 | ↑ PAK1 | [69] | |||
| miR-873-5p | ↑ CXCL16 → ↑ p-p65 and p-Rel-B, MMP1, MMP9 and MMP13 | [70] | |||
| miR-9-5p | ↑ BRAF | [67] |
PTC: Papillary Thyroid Cancer; FTC: Follicular Thyroid Cancer; ATC: Anaplastic Thyroid Cancer; MTC: Medullar Thyroid Cancer; FOXN3: Forkhead Box N3; QKI5-7: Quaking protein 5-7; SCAI: Suppressor of Cancer Cell Invasion; CXCL16: C-X-C Motif Chemokine Ligand 16; SOCS1: Suppressor Protein of Cytokine Signaling 1; MMP1: Matrix Metallopeptidase 1; VHL: Von Hippel-Lindau Tumor Suppressor; RAR-β: Retinoic Acid Receptor Beta; FOXE1: Forkhead Box E1; ITGA3: Integrin Subunit Alpha 3; HK2: Hexokinase 2; YY1: Yin Yang 1; STON2: Stonin 2; FGFR2: Fibroblast Growth Factor Receptor 2; TGF-α: Transforming Growth Factor Alpha; AKT3: RAC-γ serine/threonine-protein kinase; CCND1: Cyclin D1; FGF2: Fibroblast Growth Factor; ROCK1: Rho-associated Protein Kinase 1; PAK1: p21 Activated Kinase-1; ERBB2: Erb-B2 Receptor Tyrosine Kinase 2; FOXO1: Forkhead Box O1.