Figure 2.

Masking capability of MPA, kifunensine, and LDAO in LRW. Concentration of each component was equal to process conditions. Endotoxin recoveries for each step and corresponding water controls are shown. The initial spike was set to 10 EU/mL, followed by incubation for 24 h at 2 to 8 °C. LAC: lower acceptance criteria for endotoxin recovery (50% endotoxin recovery); (A) MPA in LRW at process concentration; (B) kifunensine in LRW at process concentration; (C) LDAO in LRW at process concentration; (D) LDAO in LRW at 50% process concentration. Y-axis: endotoxin recovery referred to water control T₀ (%); x-axis: different time points.