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. 2020 Nov 5;12(11):3269. doi: 10.3390/cancers12113269

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TSPAN1 sensitizes HNSCC cells to CDDP. (A) TSPAN1 depletion sensitizes parental and resistant cells CCL-138, JHU029 and HTB-43 to CDDP. A representative experiment is shown from at least three independent experiments. (B) Table summarizes the IC50 values (µM) from the plots shown in panel A, the IC50 values are represented graphically as the percentage of sensitization relative to control cells (assigned a value of 100%). (C) Sensitization of biopsy-derived HNSCC cell lines from four CDDP-resistant cancer patients: P33, P13 and P74 (laryngeal biopsies) and P23 (pharyngeal biopsy). A representative experiment is shown from at least three independent experiments. (D) Table summarizes the IC50 values (µM) from the plots shown in panel C, the IC50 values are represented graphically as the percentage of sensitization relative to control cells (assigned a value of 100%).