Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 5;12(11):3269. doi: 10.3390/cancers12113269

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Characterization of TSPAN1 downstream effectors. (A) Western blot analysis of proteins modulated by TSPAN1 depletion in HNSCC cells, including various key proteins related to autophagy and SRC/AKT/ERK signaling pathways. (B) Representative electronic microscopy images in TSPAN1-depleted cells vs. control cells (NC) in CCL-138 and CCL-138-R cells. TEM images revealed autophagosomes and autophagolysosomes, characteristic features of autophagic cells. (C) Quantification of autophagic vesicles from each experimental group. Note that autophagy vesicles decrease in CCL-138 cells upon TSPAN1 depletion. Unpaired two-tailed Student’s t-test, *** (p < 0.001).